Chao-Lin Liu   Professor

Phone: (02) 2908-9899 ext.6105/7300

Fax:(02) 2908-3072

Email: clliu@mail.mcut.edu.tw

Office: Room109-1, General Building

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Research Interest

1. Enzymomics
Enzymoomics is the discipline studing on the enzymome, the set of enzymes. The profiles of those enzymes activities in different parameters, such as pH, temperature and so on, can be monitored and identified by. two-dimensional electrophoresis (2DE), zymography and mass spectrometry. By the technique, a bunch of chitinases were observed. Some unique chitinases were identified, expressed and patented. The discipline also applied on diseases involving enzymes activities, 

2. Chitinasome
Chitin is the polymers composed with the monomer, N-acetyl glucosamine. It is an abundant polysaccharide and distributed in various organisms, such as crustaceans, fugi, and insects. Microbes degrade chitin with multiple chitinolyc enzymes for carbon and nitrogen sources. Recently, chitinasome, a protein complex producing N-acetyl glucosamine by chitin cleavage, was identified. The protein and bioseparation techniques are applied for elucidation on the subunits and mechanism of chitinasome.

3. Intellectual property and biosafety

Education

Ph. D.: College of Medicine, National Taiwan University

B. Pharm.: School of Pharmacy, National Taiwan University

LL. M.: School of Law, Washington University in St. Louis

LL. B.: Department of Law, National Taipei University

Reviewed Articles

1. The Correlation between Chitin and Acidic Mammalian Chitinase in Animal Models of Allergic Asthma (2015, Chia-Rui Shen, Horng-Heng Juang, Hui-Shan Chen, Ching-Jen Yang, Chia-Jen Wu, Meng-Hua Lee, Yih-Shiou Hwang, Ming-Ling Kuo, Ya-Shan Chen, Jeen-Kuan Chen, Chao-Lin Liu, International journal of molecular sciences 16 (11), 27371-27377)
2. Structural alterations, pore generation, and deacetylation of α-and β-chitin submitted to steam explosion (2015, TS Tan, HY Chin, ML Tsai, CL Liu, Carbohydrate polymers 122, 321-328)
3. Production of hexaoligochitin from colloidal chitin using a chitinase from Aeromonas schubertii (2014, CL Liu, CY Lan, CC Fu, RS Juang, International journal of biological macromolecules 69, 59-63)